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Silvateam Wins Innovation Award at Polyphenols Congress

Silvateam was very pleased to participate to the 11th World Congress on Polyphenols Applications: Vienna Polyphenols 2017. The event was organised by the International Society of Antioxidants in Nutrition and Health (ISANH) and the Scientific Committee in the beautiful city of Vienna, Austria, on June 20-21, 2017.

Silvateam, recognised worldwide as leader in the production and sales of tannins since 1854, took actively part in the congress, providing a gold sponsorship and presenting its wide tannin portfolio in a dedicated stand.

During its 160 years of history the company has acquired an extensive experience and technical knowledge in extracting only the best of nature and providing sustainable, cost-effective, multi-purpose solutions for a wide variety of uses, ranging from leather tanning, through nutraceuticals, to functional food, wine and beer, cosmetics, pharma, animal health & nutrition, agriculture and many other applications.

Research & Development plays a key role in all polyphenols related sectors, therefore Silvateam has always invested in both basic and application oriented research. The research is carried out not only in-house, but also in the most prestigious independent institutes such as universities and research centres in Europe, the Americas and Asia. One of this study, investigating the role of tannins as antibiotic alternative in animal nutrition, has been presented during the conference. Participating to this renowned event has been a unique occasion to meet a lot of illustrious experts and start discussing further co-operation opportunities.

At the end of the congress, the organiser awarded Silvateam a prize for its highly innovative solutions in tannins. An expert panel carried out a technical assessment in order to select the best innovations related to polyphenols application fields.

The innovation prize awarded to Silvateam was due to its ability to promote tannins as natural polyphenols in a wide range of applications using various plant sources, such as chestnut, quebracho, tara, gallnuts, grape and other exotic woods, widely available in nature. The direct access and strict control over raw materials allows Silvateam to guarantee the quality, availability and sustainability of its products. The extraction process is eco-friendly, as simple as making a nice cup of tea. The wood is chipped and infused in hot water to obtain a liquid tannin. After evaporation of water, tannin in powder form is commercialised all over the world.

Silvateam management was delighted of the achievement, and even more grateful of receiving recognition from such a competent audience for years of researching innovative techniques, processes and formulations.

You can surely state that nature is part of Silvateam DNA.

Samuele Giovando, R&D Director at Silvateam, Dr. Mariano E. Fernandez Miyakawa, Researcher at CONICET

More information about Silvateam: https://www.silvateam.com/en/

Who attended Vienna Polyphenols 2017?

More than 300 stakeholders from the academic, regulatory, industrial sectors, biotech and start-up gathered during Polyphenols Applications 2017 World Congress to discuss many hot topics. Among them:

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Vienna Polyphenols 2017 Abstracts Book

The Abstracts book in PDF version of Vienna Polypenols 2017 is available to order.

If you missed the conference and you would like to order the abstracts book, please click here. 

If you are member of ISANH & Attendees of Polyphenols 2017, please use following page to download PDF version of Abstracts Book.

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Antioxidant and anti - inflammatory potenti al of a pectin depleted apple pomace extract in a pilot human intervention study

Dr Jessica Walker from University of Vienna, Austria will present her studies on "Antioxidant and anti - inflammatory potenti al of a pectin depleted apple pomace extract in a pilot human intervention study" at the 11th World Congress on Polyphenols Applications in Vienne.

According to Dr Jessica Walker, based on the in vitro antioxidant and anti-inflammatory properties of pectin-depleted apple pomace extract (APE4), a human intervention study was performed. Each intervention phase of this placebo controlled pilot study in diabetic and heavily-overweight to obese women spanned over 4 weeks, separated by a 4-week wash-out phase. Upon 4-week intervention with encapsulated APE4, body weight or composition remained unaffected, while endotoxin-stimulated inflammation was reduced.

For more information, please visit www.polyphenols-site.com

The chemistry of gut microbial metabolism of dietary polyphenols

Prof. Fred Stevens, Professor of Pharmaceutical Sciences at the College of Pharmacy and Director a.i at the Linus Pauling Institute from Oregon State University, USA will present his studies on the chemistry of gut microbial metabolism of dietary polyphenols at the 11th World Congress on Polyphenols Applications in Vienne. 

According to Professor Stevens epidemiological evidence suggests a positive relationship between intake of polyphenol-rich foods and health. However, experimental evidence from preclinical models has not provided a satisfactory explanation for the health-promoting effects of dietary polyphenols in humans. The research community has begun to recognize the impact that gut microbiota have on the health benefits of polyphenols. Not only do gut microbiota affect bioavailability of dietary polyphenols but also their biological activity, because polyphenol-derived metabolic products often have biological properties that are different from the parent polyphenols. Therefore, knowing how gut microbiota metabolize polyphenols is as important as knowing how bioavailable polyphenols affect the health of the host.

For more information, please visit www.polyphenols-site.com

Dietary Polyphenols: Nrf2, epigenetics and in vivo efficacy

Pr Ah-Ng Tony Kong from the Center for Epigenomics of Natural Products, Ernest Mario School of Pharmacy, Rutgers University at Piscataway, USA will give a presentation about Dietary Polyphenols: Nrf2, epigenetics and in vivo efficacy during Vienna Polyphenols World Congress 2017.

According to Pr Kong: "Imbalance between reactive oxygen species (ROS)/reactive nitrogen species (RNS) and the anti-oxidative stress defense systems in cells creates excessive oxidative stress and inflammatory conditions that drive many diseases including cancer. ROS/RNS or carcinogen metabolites can attack intracellular lipids, proteins, nucleic acids, and other macromolecules which can result in epigenetic modifications, genetic mutations, and carcinogenesis. Nrf2, a master regulator of antioxidant defense system plays a critical role in the regulation of many antioxidative stress/antioxidant and detoxification enzymes, such as glutathione S-transferases (GSTs), NAD(P)H:quinone oxidoreductase 1 (NQO1), UDP-glucuronyl transferases (UGTs), and heme oxygenase-1 (HO-1), via the antioxidant response element (ARE). Numerous studies have shown that many dietary phenolic phytochemicals possess anti-cancer preventive property through the induction of Nrf2-mediated antioxidant/detoxification enzymes coupled with the anti-inflammatory signaling pathways that protect organisms against cellular damages caused by oxidative stress. [...] Discussions will include the failure of some polyphenols to activate the Nrf2 system, apparent lack of in vivo efficacy and failed clinical trials."

About Pr Kong: Ah-Ng Tony Kong is Distinguished Professor, Glaxo Endowed Chair Professor of Pharmaceutics and Director of the Graduate Program in Pharmaceutical Sciences at Rutgers, The State University of New Jersey. He is the Director of a new Center for Epigenomics of Natural Products on Inflammatory Diseases. Dr. Kong received his B.S. in Pharmacy with First Class Standing from the University of Alberta, Canada and his Ph.D. in Pharmaceutics, Pharmacokinetics and Pharmacodynamics from the State University of New York at Buffalo. He received his post-doctoral training in molecular genetics and cellular signaling at the National Institutes of Health (NIH). He was on the faculty of Thomas Jefferson University Medical School and the University of Illinois at Chicago prior to joining Rutgers in early 2001. Dr. Kong serves on the NIH Study Section since 1999 and he has been continued receiving funding support from the NIH since 1993. He has trained more than 50 visiting professors, post-doctoral fellows, and Ph.D. students. He has published more than 230 original research, review articles and book-chapters. He has chaired and given presentations in many National and International Symposia. He teaches in Pharmacy and Pharmaceutical Sciences, Biopharmaceutics, Pharmacokinetics and Drug Metabolism to the PharmD and Ph.D./M.S. Students. He is the Founding Editor-in-Chief of the online journal Current Pharmacology Reports (Springer), Associate Editor of Molecular Carcinogenesis, and member of editorial advisory boards of many journals including Cancer Prevention Research (AACR), Scientific Reports (Nature), and Biopharmaceutics and Drug Disposition. His research areas are in dietary & Traditional Chinese Medicine phytochemicals (signaling and gene expression, nutrigenomics, epigenomics, cancer prevention), animal cancer models, epigenetics, oxidative/redox/inflammatory stress response and Nrf2-mediated nuclear transactivation & signaling, pharmacokinetics/pharmacodynamics and PK-PD modeling of phytochemicals.

Molecular basis of the specificity and efficacy of resveratrol against cancer

Professor Wolfgang F. Graier from the Institute of Molecular Biology and Biochemistry and Medical University of Graz, will give a talk at the 11th World congress on Polyphenols Applications about the molecular basis of the specificity and efficacy of resveratrol against cancer.

According to Prof. Graier, resveratrol and its derivate piceatannol are found to selectively cancer cell death.Professor Graier team work concentrated on the molecular mechanisms of this cancer selectivity. They observed that the functionally and/or physically tethering of the mitochondria to the endoplasmatic reticulum is greatly enhanced, thus, leading to an attenuated engagement of mitochondria to the cancer cells energy metabolism and ER ATP homeostasis.

The polyphenols take advantage of the enforced inter-organelle coupling and trigger apoptotic cancer cell death by their rather exclusive reduction of mitochondrial ATP content that affects ER Ca2+ handling yielding mitochondrial Ca2+ overload and subsequent cancer cell death.

Find out more : www.polyphenols-site.com

Valorization of agri-food by-products by extracting valuable bioactive compounds using green processes

Dr Krasimir Dimitrov, from the Charles Violette Institute at Lille University, France is invited during Vienna Polyphenols World Congress to give a talk about the valorization of agri-food by-products by extracting  valuable bioactive compounds using green processes.

During his presentation, Dr Dimitrov will highlight the main green extraction processes applied for recovery of bioactive compounds from agri-food by-products, such as
enzyme-assisted extraction (EAE), ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE), pressurized liquid extraction (PLE) and supercritical fluid extraction (SFE) are presented, as well as some processes, such as pulsed electric fields (PEF) and high voltage electrical discharges (HVED) that could be applied both in pretreatment stage and during the extraction process.

Another pretreatment process, instant controlled pressure drop (DIC process), allowing to enhance considerably the extraction process is also described. For each process, will be discribed the principle and some examples of its application for recovery of valuable bio-molecules (mainly polyphenols) from agri-food by-products. The green impact of each process is related to the “6 principles of the green extraction”.

Finally, some examples of simultaneous application of at least two processes (hybrid extraction processes) and process integration allowing to enhance the extraction yields and to obtain enriched natural extracts at reduced time and energy (integrated processes)will be presented. 

To know more about these techniques, come & join Vienna Polyphenols 2017: www.polyphenols-site.com

A response to quercetin-exposure: dendritic cells iron export as the first step towards tolerance

Doctor Stefania De Santis from ISPA-CNR in Lecce,Italy, will give a talk at the 11th World Congress on Polyphenols Applications.

According to Doctor De Santis, plant polyphenols consumption is encouraged in healthy dietary regimes due to their antioxidants and anti-inflammatory effects.
These organic molecules exhibit numerous properties including phytochelation; the ability to create complex with metal ions. Among polyphenols, the team of Doctor De Santis focused their attention on quercetin demonstrating its ability to reduce dendritic cells (DCs) inflammatory cytokine secretion and antigen presentation following LPS exposure in vitro and in vivo.

Recently, they demonstrated that quercetin exerts these functions by affecting DCs iron homeostasis. After quercetin exposure, DCs export iron in the extracellular compartment and, at the same time, induce a genes pathway related with iron homeostasis and inflammatory suppression. Future studies are needed to address if administration of natural bio-chelators can reduce inflammatory cytokine secretion by intestinal resident macrophages and DCs, a crucial step to promote the resolution of inflammation and tissue repair.

For more information www.polyphenols-site.com/

Sirtuins, a promising target in slowing down the ageing process; regulatory role of polyphenols

Dr Anna Bielak-Żmijewska from the Laboratory of Molecular Basis of Ageing, the Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland, will give a talk at the 11th World Congress on Polyphenols Applications about the role of sirtuins, called the enzymes of youth, in the regulation of cellular senescence and ageing, and the role of polyphenols in activation of these enzymes.

Aging is an inescapable/unavoidable process. However, the existing data prove that it is malleable and can be effectively slowed down. Ageing is characteristic for almost all living organisms. We are getting older because our cells senesce. Cellular senescence leads to increased low grade inflammation and impairs proper functioning of tissues and organs. One of the promising targets for anti-aging medicine are sirtuins, enzymes strongly involved in DNA repair, telomere maintenance, epigenetic modification of both histones and DNA, and in regulation of many processes involved in homeostasis maintenance in the whole organism. Searching for activators of these enzymes is currently one of the most promising elements of anti-aging strategy and one of the least invasive approaches. It is suggested that some polyphenols are full of promise as activators of sirtuins.

For more information: www.polyphenols-site.com

Curcumin in combination with chemotherapy: Presentation of the CUFOX story

During Vienna Polyphenols World Congress, Dr Lynne Howells from University of Leicester will present the recent study concerning Curcumin in combination with chemotherapy.

According to Dr Howeels: "Combining low toxicity polyphenolic adjuncts with standard-of-care chemotherapy may offer added benefit to patients without increasing side effect burdens. Here, we have taken a bench to bedside approach, examining the effects of curcumin in combination with oxaliplatin-based therapy in colorectal cancer. Promising in vitro and pre-clinical data has led to the work-up of the CUFOX phase I/IIa trial, combining curcumin with FOLFOX-based chemotherapy in patients with metastatic colorectal cancer."

The results of this study will be presented during Vienna Polyphenols World Congress: www.polyphenols-site.com

What are the risks and benefits of conducting realistic research on polyphenols?

Dr. Pedro Mena, from The Laboratory of Phytochemicals in Physiology, Department of Food & Drug, University of Parma, Italy, will give a talk at the 11th World Congress on Polyphenols Applications about the risks and benefits of conducting realistic research on polyphenols.

Experimental realism refers to adhering to physiological conditions when performing research on polyphenols. This should be kept in mind at all research levels, from cell studies to human interventions. Dosages, molecules, experimental designs, etc., should all be built over physiological assumptions in order to make polyphenol research translatable and really useful. By risking a little more in polyphenol research, we (researchers and humans) will benefit a lot!

For more information: www.polyphenols-site.com

What is the impact of long-term consumption of anthocyanin-rich fruit juice on antioxidative markers and gut microbiome?

One of the strategic topic of Vienna Polyphenols 2017 is to talk about Gut Microbiota & Polyphenols. During this session, Dr David Berry from Unviersity of Vienna, Austria will highlight the impact of a long-term consumption of anthocyanin-rich fruit juice on antioxidative markers and gut microbiome.

As mentioned by Dr Berry, multiple degenerative diseases are associated with oxidative stress and damage, which has raised the question whether an antoxidant-rich diet can improve health. In the study which will be presented during Vienna Congress, Dr Berry's team examined the effect of daily consumption of anthocyanin-rich juice by healthy volunteers over a 2 month period.

The results will be presented during Vienna Polyphenols World Congress: www.polyphenols-site.com

Reaction products of enzymatic and chemical oxidation of polyphenols

Processing of food inevitably encompasses steps which expose the contained polyphenols to oxidative conditions leading to numerous reactions that primarily modifies the genuine polyphenol profile and may eventually end in degradation of the polyphenols. The result of this oxidation can be assessed as a severe loss of quality of the food since polyphenols account for sensory attributes as well as health promoting effects. 

During Vienna Polyphenols World Congress, Dr Fabian Weber from the University of Bonn, Germany will present the different reaction products of enzymatic and chemical oxidation of polyphenols.

For more information: www.polyphenols-site.com

Natural products inducing macrophage cholesterol efflux: Presentation of the recent scientific data

During Vienna Polyphenols World Congress, the scientific committee invited Dr Atanas Georgiev Atanasov from tje University of Vienna, Austria to give a presentation about Natural products inducing macrophage cholesterol  efflux: Presentation of the recent scientific data.

According to Dr Atanasov: Cardiovascular disease is the major cause of death in the world, and therefore the identification of compounds that can combat it is highly relevant. Presented will be the characterization of natural products able to enhance macrophage cholesterol efflux, an anti-atherosclerotic process counteracting the transformation of macrophages into cholesterol-enriched proatherogenic foam cells."

For more information about this strategic talk, come & join Vienna Polyphenols 2017: www.polyphenols-site.com

What are the recent advances in the analysis of polyphenols in physiological samples?

Polyphenols have been associated with various beneficial activities such as antioxidative, anti-inflammatory or antiproliferative effects. Their metabolites appear in very low concentrations in biological fluids like plasma or urine, rarely exceeding nmol/l levels. In view of the complex matrix and the large number of compounds, usually present in low quantities, methods used for the analysis of polyphenols and their metabolites need to be highly selective, sensitive, reliable, and accurate. Appropriate sample preparation is very important and constitutes a prerequisite for the successful analysis of polyphenols. It is essential to ensure the applicability of the analytical methods with a comprehensive validation.

During Vienna Polyphenols World Congress 2017, Dr Maike Passon, from University of Bonn, Germany will present these recent advances in the analysis of polyphenols in physiological samples.

For more information: www.polyphenols-site.com

Welcome to Vienna Polyphenols 2017

Dear Colleagues,

On behalf of the International Society of Antioxidants in Nutrition and Health (ISANH) and the Scientific Committee, we are pleased to announce the organization of the 11th World Congress on Polyphenols Applications: Vienna Polyphenols 2017 to be held at the University of Vienna, Austria next June 20 & 21, 2017.

The 11th Polyphenols World Congress will bring together experts from academia and industries to discuss the latest scientific advances in the field of polyphenols and their uses to improve human health.

Vienna Polyphenols 2017 two-day conference will highlight the following strategic subjects:

• Analysis, Mechanistic and clinical aspects
• The toxicological aspects of polyphenols
• Interactions between polyphenols and gut microbiota
• Extraction, valorization and analysis of polyphenols from food and by-products
• Applications of polyphenols in foods, beverages and cosmetics
• Innovations with polyphenols

A general discussion will be held at the end of the second day about Polyphenols 2017: What’s next?

We look forward to welcoming you in lovely Vienna for this special event. Please visit the website of Visit Vienna to enjoy an extraordinary moment where sightseeing, gastronomy, art, history meet.

Doris Marko

Local Organizing Committee

 Andreas Schieber

President of Vienna Polyphenols 2017

Porto Polyphenols 2016: Concluding Remarks by Pr Andreas Schieber

The 10th International Conference on Polyphenols Applications took place in Porto, Portugal, from June 29 to July 1, 2016 under the auspices of the International Society for Antioxidants in Nutrition and Health (ISANH).

Dr. Andreas Schieber, President of Porto Polyphenols 2016, Dr. Marvin Edeas, President of ISANH, Dr. Fernanda Borges and Dr. Jorge Garrido, the local organizers from the University of Porto welcomed more than 300 academics and industry representatives from 27 countries at Porto Instituto Superior de Engenharia do Porto.

Taking into consideration recent advances in research on polyphenols, Porto Polyphenols 2016 covered as oral and poster presentations topics of utmost interest, for example, bioavailability and metabolism, extraction of polyphenols from by-products, role of polyphenols in health and disease, and polyphenols applications in foods and beverages. Short oral presentations greatly enriched the congress by addressing additional topics.

The 2016 Poster Award was bestowed upon Dr Eva Anzenbacherova and Dr Pavel Anzenbacherov, from Palacky University, Department of Medical Chemistry and Biochemistry, Czech Republic for their presentation about Gut microbiome species richness differ after intake of green tea and cranberry extracts by lean and obese mice.

The scientific committee and the local organizers expressed their appreciation to all participants for their excellent contributions, which made also the 2016 edition of the International Conference on Polyphenols Application a success.

Please click here to visit the 3-days Porto Polyphenols Congress photos.

Please click here to access to the final program of Porto Polyphenols Congress.

We look forward welcoming for the 2017 world congress.

Porto Polyphenols Secretariat

Come & network with academics and industrial stakeholders during Porto Polyphenols Congress

On behalf of the Organizing Committee, we are pleased to inform you about the updated list of universities & companies who will attend Porto Polyphenols World Congress 2016:

Cara Partners, Centro Ricerche per la Chimica Fine Srl, FDT Consulting Engineers & Project Managers, GBT Spain, Herbalife, MIAVIT...

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Influence of coffee consumption on DNA integrity in humans

Pr. Elke Richling from the University of Kaiserslautern, Germany, will speak about the Influence of coffee consumption on DNA integrity in humans at Porto Polyphenols Congress 2016.

Pr. Richling concludes the following about her topic: Epidemiologic evidence suggests coffee consumption to be associated with reduced risk due to certain diseases, including diabetes type 2, Parkinson, and cardiovascular disease or various types of cancer. In human interventions studies we investigated effects of regular coffee consumption on DNA integrity in peripheral white blood cells (WBC) by the comet assay. During four weeks, volunteers daily ingested three large cups (250 ml) of a specific coffee blend, rich in both, green bean constituents and roast products. Controls received the same volume of water. The results allow the conclusion that regular coffee consumption is associated with markedly reduced DNA strand breaks, reflecting total as well as background DNA damage. In a recently performed short term study, when volunteers consumed four cups of coffee (200 ml) every two hours the results showed a significant reduction of background DNA strand breaks in comparison to baseline. Interestingly, this DNA protective effect was detected already two hours after the first coffee consumption.Taken together, our studies clearly showed that consumption of coffee reduces DNA damage in white blood cells of humans.