News Alert

Impact of Berries, Cherries and Quinoa Polyphenols on Gut Microbiota & Health

Dr. Franck Carbonero, from the Washington State University-Spokane, USA, will join us this year to present a talk entitled “Impact of Berry and Quinoa Polyphenols on Gut Microbiota & Health”.

It is now well established that bioavailability and bioactivity of a significant fraction of dietary polyphenols are directly modulated by the gut microbiota.

A better understanding of both the impact of polyphenol on gut microbiota profiles and the fate of microbial phenolic metabolites is primordial to optimize nutritional strategies relying on polyphenols expected antioxidant properties. Furthermore, considering the whole polyphenol-rich foods should become the gold standard, as the complete physiochemical properties of the food matrix also influences the polyphenol/microbiome/host interactions.

Dr. Carbonero will present his most recent findings on the impacts of polyphenols from berries, cherries and quinoa on the gut microbiota as informed by in vitro, animal and human studies.

You can find more information on Dr. Carbonero's research and publications on his website: https://labs.wsu.edu/ngmb/

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Micellar Formulations Enhance the Post-Digestive Solubility and Bioavailability of (Poly)phenols

Dr. Jan Frank, from the University of Hohenheim, Germany, will join us this year to present a talk entitled “Micellar Formulations Enhance the Post-Digestive Solubility and Bioavailability of (Poly)phenols”.

The bioavailabilities of (poly)phenols are determined by their digestive stability, absorption in the small intestine, their subsequent biotransformation, and distribution in or elimination from the organism.

Different strategies targeting some of these processes have been developed to enhance the bioavailabilities of (poly)phenols, but only a few have been successful.

Dr. Frank will present his most recent findings on successful formulation strategies to enhance the oral bioavailabilities of (poly)phenols in humans and on the potentially underlying mechanisms of action.

You can find more information on Dr. Frank's research and publications on his website: www.nutrition.red

Join us in polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Frank.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Antioxidant Activity and Phenolic Composition of Extracts Obtained from Microalgae After the Application of Innovative Processes

Dr. Francisco Juan Martí-Quijal, from the University of Valencia, Spain, will join us this year to present a talk entitled “Antioxidant Activity and Phenolic Composition of Extracts Obtained from Microalgae After the Application of Innovative Processes”.

Microalgae are an important source of nutrients and bioactive compounds (e.g. polyphenols), and therefore can be considered as interesting ingredients in the development of new functional foods and nutraceutical products. Different extraction methods can be used to obtain microalgae compounds with high added value. In this sense, non-conventional extraction technologies like pulsed electric fields, supercritical fluids extraction, and enzymatic extraction, among others, can be useful to make this process more sustainable since conventional extraction methods can be slow, consume large amounts of solvent, work at high temperatures, or extract unwanted compounds. Treatment and extraction conditions can influence the phenolic profile and antioxidant activity of the obtained extracts.

Join us in Polyphenols Applications 2022 to know more about this topic.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Innovative Technologies for the Extraction of Antioxidant Bioactive Compounds from Mushrooms

Ms. Mara Calleja, from the University of Valencia, Spain, will join us this year to present a talk entitled “Innovative Technologies for the Extraction of Antioxidant Bioactive Compounds from Mushrooms”.

In recent years, the growing production and consumption of mushrooms has led to an increase in research on this food group, both as a source of bioactive components and as additives for the formulation of supplements and nutraceuticals. Bioactive compounds such as polyphenols present in mushrooms show antioxidant properties and the ability to interact with components of the organism being useful for the design of new therapeutic agents.

For this reason, new sustainable extraction methods are being sought, such as Pulsed Electric Field-Assisted Extraction, which increases the quality of the extract and saves energy. This method is applied in the extraction of antioxidant compounds in samples of A. bisporus, L. edodes, A. brunnescens and P. ostreatus, also affecting the microstructure, which is evaluated by scanning electron microscopy.

Join us in Polyphenols Applications 2022 to know more about this topic.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Recovery of Polyphenols from Medicinal Plants Extracts Assisted by Pulsed Electric Fields

Dr. Noelia Pallarés, from the University of Valencia, Spain, will join us this year to present a talk entitled “ Recovery of Polyphenols from Medicinal Plants Extracts Assisted by Pulsed Electric Fields”.

Join us in Polyphenols Applications 2022 and benefit from the experience of professional researchers like Dr. Pallarés.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Chemistry and Pharmacology of Cannabinoids

Dr. Jan Frederik Stevens, from Oregon State University, USA, will join us this year to present his most recent findings on “Chemistry and Pharmacology of Cannabinoids”, during Cannabis 2022 workshop.

He will share his newest work and his vast knowledge on Cannabinoids from a pharmacological perspective.

Remember that you too can participate in Cannabis 2022 by submitting your abstract here.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Inhibition of Oxytosis/Ferroptosis by Cannabinol Requires Mitochondria and is Independent of Cannabinoid Receptors

Dr. Pam Maher, from the The Salk Institute for Biological Studies, USA will join us this year to present her most recent findings on "Inhibition of oxytosis/ferroptosis by cannabinol requires mitochondria and is independent of cannabinoid receptors".

The oxytosis/ferroptosis regulated cell death pathway recapitulates many features of mitochondrial dysfunction associated with the aging brain and has emerged as a potential key mediator of neurodegeneration. It has thus been proposed that the oxytosis/ferroptosis pathway can be used to identify novel drug candidates for the treatment of age-associated neurodegenerative diseases that act by preserving mitochondrial function. Previously, we identified cannabinol (CBN) as a potent neuroprotector.

Here, Dr. Maher demonstrates that not only does CBN protect nerve cells from oxytosis/ferroptosis in a manner that is dependent on mitochondria, it does so independently of cannabinoid receptors.

Specifically, CBN directly targets mitochondria and preserves key mitochondrial functions including redox regulation, calcium uptake, membrane potential, bioenergetics, biogenesis, and modulation of fusion/fission dynamics that are disrupted following induction of oxytosis/ferroptosis.

These protective effects of CBN are at least partly mediated by the promotion of endogenous antioxidant defenses and the activation of AMP-activated protein kinase (AMPK) signaling.

Together, her data highlight the potential of mitochondrially-targeted compounds such as CBN as novel oxytotic/ferroptotic inhibitors to rescue mitochondrial dysfunction as well as opportunities for the discovery and development of future neurotherapeutics.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Ocular Delivery of Polyphenols

Dr. Yolanda Diebold, from the Universidad de Valladolid, Spain will join us this year to present his most recent findings on "Ocular Delivery of Polyphenols".

Polyphenolic compounds are good scavengers of free radical species. This, among other medicinal effects, permits them to interfere with different molecular pathways that are involved in the inflammatory process. Oxidative stress or inflammatory processes are the basic etiological mechanisms of many ocular pathologies.

In her talk, Dr. Diebold will focus on the polyphenolic compounds that have been proved to be efficient in suppressing some of the indicators of these ocular pathologies in in-vitro and in-vivo models. She will also discuss drug delivery strategies to formulate polyphenolic compounds to treat oxidative stress and inflammation related ocular pathologies will be mentioned.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Procyanidin C1 is a natural agent with senolytic activity against aging and age-related diseases

Dr. Yu Sun, from the Chinese Academy of Sciences, China will join us this year to present his most recent findings on "Procyanidin C1 is a natural agent with senolytic activity against aging and age-related diseases".

Aging is associated with physical function decline and senescent cell accumulation in various tissues and organs. Senolytic agents such as dasatinib and quercetin (D+Q) in combination have been shown to target senescent cells and ameliorate symptoms of aging-related disorders. However, cell type specificity and cytotoxicity have substantially restrained their clinical development. Dr. Sun recently expanded the senolytics arsenal by revealing a natural agent (flavonoid) that has senotherapeutic activity and prolongs healthspan and lifespan in preclinical trials, thus providing a new modality for future application of polyphenols.

Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain
www.polyphenols-site.com

Best Oral Presentations of Polyphenols Applications 2021

Many Short Oral Presentations were submitted during the 14th World Congress on Polyphenol Applications, held on September 22-24 2021. The attendees voted for the best 3 of these short oral presentations.

Best Short Oral Presentation Award #1

Chosen by the attendees, Nicole Nemetz was discerened an award for her short oral presentation about the Strategies for the Valorization of Berry Pomace in the Food Industry. 

Nicole Jasmin Nemetz is currently PhD Student at the University of Bonn (Germany) in the Institute of Nutritional and Food Science, Molecular Food Technology. She is working on the resource-saving processing of berry juice and focused in this study on the recovery of the berry pomace. The goal was a coloring foodstuff (pomace powder) for the applicability in e.g. yogurt.

Best Short Oral Presentation Award #2

Sara Ferraris, PhD in Biomedical Engineering - Politecnico di Torino (Italy), received the best short oral presentation award for her contribution "Polyphenols from Grape Pomaces for the Modulation of the Biological Response of Bioactive Materials". She is active in the field of surface modification and characterization of biomaterials as well as in the design of customized ageing test, durability, stability and release tests.

The research described in the presentation was performed in the framework of an international project NAT4MORE (NATural molecules on the surface of bioactive materials FOR MOdulating the host REsponse to implants, M-ERANET call 2016) coordinated by Politecnico di Torino (DISAT, prof. S. Spriano) in collaboration with Consiglio per la Ricerca in agricoltura e l‟analisi dell‟Economia Agraria (CREA), Innovation Centre Iceland (ICI), Genis (Iceland) and Universidade de São Paulo (USP, Brasil). The project is focused on the extraction of natural molecules (e.g. polyphenols) from local byproducts (e.g. grape pomaces) and graft them to biomaterials (titanium, bioactive glasses and hydroxyapatite) to modulate their biological response. Effective protocols for the functionalization of biomaterials with natural polyphenols and for the characterization of functionalized biomaterials were developed and presented. 

Best Short Oral Presentation Award #3

Maria Chiara Di Meo, PhD student in Science and Technology for the Environment and Health at the Department of Science and Technology of the University of Sannio (Benevento, Italy), was discerned an award for her short oral contribution "Characterization and Antioxidant Activity of Bioactive Molecules Extracted from Olea europaea Leaves".

The research group in which she is involved has been working for a long time on the valorisation of bioactive molecules extracted from by-products of agro-food industries and their use in different fields of application. In particular, recent studies have focused on the antioxidant and anti-inflammatory activity of bioactive molecules extracted from plant matrices for their use in the formulation of functional and nutraceuticals feeds administered to farm animals. In this study, the phenolic profile extracted from olive leaves in different phenological phases was characterised and the antioxidant activity of bioactive molecules on erythrocytes of trout Oncorhynchus mykiss was evaluated.

Polyphenols Applications 2021 Congress
September 22-24, 2021 - Interactive Online Congress
www.polyphenols-site.com

Best Poster Presentations of Polyphenols Applications 2021

During the 14th World Congress on Polyphenol Applications which was held as an interactove online event from September 22 to September 24 2021, the participants voted for the Best Poster Presentations.

Best Poster Presentation Award #1

The first award for the Best Proster Presentation was discerned to Teresa Herrera, PhD in Food Science and Technology, for her presentation on the "Development of Sustainable and Healthy Yogurts with Extracts of Wild Fruits Rich in Polyphenols".

Ms. Herrera's scientific career is mainly engaged in research  respect to bioactive compounds, extraction and characterization in legumes and fruits and also in the development of novel dairy products. 

"Our study is based on development novel healthy dairy products elaborated with extracts obtained of wild fruits rich in polyphenols. First, we evaluated and characterization wild fruits extracts, and selected the more interesting ones. Then,  produce yogurts that incorporate these wild fruits extracts  with antioxidants of natural origin as ingredients. This way can be a successful strategy for novel product development and could be valuable potential sources of safe and inexpensive antioxidants of natural origin in yogurts."

Best Poster Presentation Award #2

Another award for the Best Poster Presentation was given to Paulina Tapia Quirós, from Universidad Politécnica de Cataluña (Spain). She presented a poster about "Total Polyphenol Content and Antioxidant Capacity of Agri-Food Wastes: Estimation by Spectrophotometric Assays and High-Performance Liquid Chromatography".

"This study is dedicated to the valorization of agri-food wastes. In particular, this work is focused on the determination of the total polyphenol content (TPC) and antioxidant capacity from residues of the olive oil and wine production through different analytical techniques. For that purpose, some spectrophotometric assays (e.g. Folin-Ciocalteu (FC), 2,-diphenyl-1-picrylhydrazyl (DPPH), 2,2-azinobis-3-ethylbenzothiazoline-6-sulfonat (ABTS), ferric reducing antioxidant power (FRAP)), and high-performance liquid chromatography (HPLC-UV) technique were used. Overall, the recovery of polyphenols from these agri-food wastes could provide a sustainable solution to olive oil and winery sectors."

Polyphenols Applications 2021 Congress
September 22-24, 2021 - Interactive Online Congress
www.polyphenols-site.com

Best Scientific Award of Polyphenols Applications 2021

The Best Scientific Award of Polyphenols Applications 2021 was discerned to Dr. Mark Willems, Professor of Exercise Physiology in the Institute of Sport, Nursing and Allied Health at the University of Chichester in the United Kingdom. This award was given for his presentation about "Anthocyanin-Rich New Zealand Blackcurrant: Applications for Exercise and Health"

"Since 2013, studies were undertaken on the effects in humans by the intake of New Zealand blackcurrant powder and extract on exercise-induced physiological responses, exercise performance, and health parameters. The work has shown the beneficial in vivo effects of an anthocyanin-rich berry with application for athletes and the general population." 

Beneficial Effects of Cornelian Cherry polyphenols on NO/ROS Balance in Obese Zucker Rats

Prof. Olga Pechanova from Slovak Academy of Sciences, Slovakia will give a presentation entitled Beneficial Effects of Cornelian Cherry polyphenols on NO/ROS Balance in Obese Zucker Rats.

Prof. Pechanova will highlight about Cornelian cherries (CCs) that belong to promising anti-obesity substances. They aimed to study effects of coenzyme Q10 (CoQ10) and two varieties of CCs (Koralovij Marka and Wilde Type) on lipid profile, ROS, and nitric oxide (NO) production in obese Zucker rats. CoQ10 did not affect plasma lipid profile and NOS activity either in the heart left ventricle or aorta. On the other hand, Wilde Type decreased cholesterol and LDL levels. Koralovij Marka and Wilde Type increased NOS activity in the aorta, while not affecting the activity in the heart left ventricle. Koralovij Marka increased eNOS expression and did not affect ROS production, while Wilde Type increased SOD and decreased NADPH oxidase without affecting eNOS expressions in both tissues. In conclusion, CCs showed better beneficial effects than CoQ10 in all parameters studied.

Polyphenols Applications 2021 Congress
September 22-24, 2021 - Digital Congress
www.polyphenols-site.com

Polyphenols Applications: Neutraceutical Interventions for Peripheral Artery Disease

Dr. Mary McGrae McDermott, from Northwestern University, USA, will give a talk entitled "Polyphenols Applications: Neutraceutical Interventions for Peripheral Artery Disease" during the congress in September.

Polyphenols Applications 2021 Congress
September 22-24, 2021 - Digital Congress
www.polyphenols-site.com

Secoiridoids from Gentiana Lutea: Interaction with Bitter Receptors in the Gastrointestinal Tract and Enteroendocrine Pharmacological Application

Prof. Luigi Milella, from Università della Basilicata, Italy, will join Polyphenols Applications 2021. Prof. Milella will give a talk about "Secoiridoids from Gentiana Lutea: Interaction with Bitter Receptors in the Gastrointestinal Tract and Enteroendocrine Pharmacological Application".

According to his research, gentian root is known since centuries as an herbal bitter root and it has been traditionally used for several pharmacological applications. Moreover, the bitter principles of gentian root are secoiridoid glycosides like amarogentin and gentiopicrin. Recent evidences showed that bitter-tasting compounds modulate bitter taste receptors not only on the tongue but also in different parts of the gastrointestinal tract. In fact, it has been recently demonstrated as enteroendocrine in gut villi have functional bitter taste receptors and once activated they lead to release of enteroendocrine cell hormones. This latter can influence the dietary intake and there might be possibilities for studying their pharmacological application for regulating hunger and satiety.

Polyphenols Applications 2021 Congress
September 22-24, 2021 - Digital Congress
www.polyphenols-site.com

Polyphenols Metabolites & Mitochondrial Function in Health and Disease

Prof. Gunter P. Eckert, from Justus-Liebig-University Giessen, Germany, will join the Polyphenols Applications 2021. 

Prof. Eckert will present his recent studies on "Polyphenols Metabolites & Mitochondrial Function in Health and Disease".

Polyphenols Applications 2021 Congress
September 22-24, 2021 - Digital Congress
www.polyphenols-site.com

Health-Promoting Effects of Hop-Derived Polyphenols Involve Modulation of the Gut-Liver-Brain Axis

Prof. Jan Frederik Stevens, from Oregon State University, USA, will join Polyphenols Applications 2021 in September to give a talk about "Health-Promoting Effects of Hop-Derived Polyphenols Involve Modulation of the Gut-Liver-Brain Axis". 

The main idea that Prof. Stevens will discuss concerns the increasing fact that the antioxidant and anti-inflammation hypothesis for polyphenol activity offers an unsatisfactory explanation for the health-promoting effects of dietary polyphenols. He confirms that using preclinical models of metabolic syndrome combined with a multi-organ, multi-omics data generation approach, it has been found that oral treatment of mice with the hop-derived polyphenol, xanthohumol, decreases liver fat accumulation, improves glucose tolerance, and mitigates cognitive impairments via modulation of the gut microbiota, nuclear receptor signaling, and via targeting metabolism that alters bile acid composition and suppresses ceramide accumulation.

Polyphenols Applications 2021 Congress
September 22-24, 2021 - Digital Congress
www.polyphenols-site.com

Non-Covalent Interactions of Polyphenols and Polysaccharides – Friend or Foe?

It is a great pleasure to announce that Dr. Fabian Weber, from the University of Bonn, Germany, will join the Polyphenols Applications 2021 Congress this September as a major speaker. Dr. Weber will give a talk about "Non-Covalent Interactions of Polyphenols and Polysaccharides – Friend or Foe?" where he will mainly discuss the importance of non-covalent interactions of polyphenols and polysaccharides and the balance between keeping and breaking them.

To fulfill their technological, sensorial, and nutritional functions, polyphenols must be released from the plant material. Consequently, one of the main goals during food processing is their extraction. This implies the breaking of non-covalent bonds between polyphenols and cell wall polysaccharides. But these interactions tend to be very firm and resistant to breakage, thereby causing a decrease in the actual amount of released polyphenols. The downside of this release is that polyphenols are confronted with detrimental conditions, causing a rapid loss and a corresponding reduction in the nutritional and sensorial quality of the food. Simultaneously, interactions of polyphenols with polysaccharides can have protective effects. There seems to exist a balance between the need to break these interactions in order to increase their yield and to maintain these interactions in order to increase stability. It is worth mentioning that they also have an influence on the concentration of dietary fiber. The directed degradation of cell wall material can also be a tool to increase the content in soluble dietary fiber and the recovery of cell wall material from side streams can yield food ingredients that are abundant in dietary fiber and antioxidant phenolics, but also exhibit intense and vibrant hues.

Polyphenols Applications 2021 Congress
September 22-24, 2021 - Digital Congress
www.polyphenols-site.com

Understanding plant genetic and processing influences on phenolic delivery in humans

Prof. Mario G. Ferruzzi from North Carolina State University, USA will join the Polyphenols Applications 2021 Congress which will be held on September 22-24, 2021 and give a presentation entitled "Understanding plant genetic and processing influences on phenolic delivery in humans".

Polyphenols Applications 2021 Congress
September 22-24, 2021 - Digital Congress
www.polyphenols-site.com

Impact of aronia juice-based food supplement on DNA integrity in humans

Dr. Elke Richling, University of Kaiserslautern, Germany will join the Polyphenols Applications 2021 Congress and give a presentation entitled "Impact of aronia juice-based food supplement on DNA integrity in humans".

Dr. Richling will present her recent eight-week intervention study, in which she and her team investigated the effects of aronia (Aronia melanocarpa) juice-based food supplement on background and total DNA strand breaks in whole blood and response to H₂O₂-induced DNA strand breaks in isolated peripheral blood lymphocytes. The results showed a significant decrease of background DNA strand breaks after four and eight weeks of supplement consumption, compared to the wash out period. H₂O₂-induced DNA strand breaks were clearly diminished in the test group after four and eight weeks in comparison to the control group. Taken together, the consumption of the aronia juice-based food supplement contributed to the maintenance of DNA integrity in healthy volunteers.

Polyphenols Applications 2021 Congress
September 22-24, 2021 - Digital Congress
www.polyphenols-site.com