Microbiome-Polyphenol Connection: A Novel Approach to Multiple Sclerosis Treatment

In the continuous quest for effective and safe treatments for multiple sclerosis (MS), a debilitating autoimmune disease, the focus has turned towards natural substances with potent anti-inflammatory and antioxidant properties, and their interactions with the gut microbiome. Among these, polyphenols have emerged as a promising adjuvant therapy, owing to their neuroprotective effects and their ability to modulate both metabolic pathways and gut microbiota.


Molecular mechanisms of action of polyphenols in MS - Credits: Giuliana La Rosa et al., 2024

A recent review paper explores the relationship between the microbiome and polyphenols, clarifying the molecular mechanisms underlying the protective effects of polyphenols in MS. The authors focus on key compounds such as resveratrol, curcumin, luteolin, quercetin, and hydroxytyrosol, examining experiments conducted in vitro and in animal models of the disease. The review reveals how these polyphenols exert their beneficial effects through direct and indirect actions, including the ability to cross the blood-brain barrier and interact with the microbiota.

The clinical evidence supporting the use of polyphenols as an adjuvant therapy in MS is still growing, with curcumin and epigallocatechin gallate (EGCG) currently leading the way. The review also provides insights into the results of a clinical trial investigating the effects of these polyphenols in MS patients, paving the way for further research and potential therapeutic applications that target the microbiome.

Stay tuned to Polyphenols Applications 2024 this September for the latest updates and breakthroughs in the field of polyphenols and microbiome.

Read the full review.


Copyrights: Polyphenols Applications.

Polyphenols Applications 2024 Congress
September 19-20, 2024 - Milan
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