Power of Polyphenols: New Hope for Urolithiasis Treatment and Prevention

Researchers from the Huazhong University of Science and Technology, China, have published a comprehensive review that highlights the potential of dietary polyphenols in the treatment and prevention of urolithiasis, a common urological disease that is seeing an alarming rise in prevalence worldwide.

Urolithiasis, or the formation of stones in the urinary tract, has been linked to reactive oxygen species (ROS) and oxidative stress (OS), which are crucial pathogenic factors in stone formation. The review underscores the importance of dietary polyphenols, a large group of natural antioxidant compounds found in plant-based foods and beverages, in combating these factors.


Mechanisms involved in the antioxidant potential of dietary polyphenols. Credits: Hong SY, Qin BL, 2024.

The researchers cover the classification and sources of dietary polyphenols, providing a comprehensive understanding of these beneficial compounds. They also present current evidence that underscores the antioxidant potential of polyphenols against stone formation. This potential is attributed to their ability to scavenge free radicals and ROS, modulate the expression and activity of endogenous antioxidant and prooxidant enzymes, regulate signaling pathways associated with OS, and maintain cell morphology and function.

The review concludes by addressing the challenges and future perspectives of dietary polyphenols, emphasizing their potential applications in the treatment and prevention of urolithiasis. 

Stay tuned to Polyphenols Applications 2024 for more updates on the latest research and developments in the field of polyphenols and their health benefits.

Read more about the findings.

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