Combination of different probiotics and berry-derived (poly)phenols can modulate immune response in dendritic cells

Combination of different probiotics and berry-derived polyphenols can modulate immune response in dendritic cells

The immunomodulatory potential of probiotics and (poly)phenols (PP) is recognized; however, studies regarding microorganisms-PP synergisms are yet to be explored.

In a study published in the Journal of Functional Foods (Elsevier) Taverniti et al. investigated the cooperation between probiotics and berry-derived PP extracts in modulating the cytokine responses in dendritic cells.

Bacteria elicited immune responses in a strain-dependent manner. PP extracts showed different modulation of cytokine triggered by bacteria. Also with LPS, used as pro-inflammatory stimulus, PP from blueberry (BB) and cranberry (CB) most efficiently reduced IL12 production. L. paracasei LPC-S01 and B. bifidum MIMBb23sg resulted the best bacterial association in abrogating IL12 and increasing IL10.

The use of PP fraction from BB50f and CB1 with the LPC-S01 + MIMBb23sg association resulted the most efficient combinations in terms of anti-inflammatory activity.

These results provide bases for further investigation in vivo, in the perspective to develop food supplements that might conceivably deliver the single and combined benefits of probiotics and berry (poly)phenols.

In summary, berry-derived polyphenols are increasingly studied for their anti-inflammatory features. Synergism between selected probiotic strains from different species and genus might increase their immunomodulatory potential. Association of probiotics and berry polyphenolic extracts can enhance the anti-inflammatory effects. In the future, slecting and characterzing a combination of specific probiotic strains and defined berry polyphenolic extracts might be useful for the development of food supplements.

Article DOI.

Image Credits: Taverniti et al. Journal of Functional Foods (2022)

During Polyphenols Applications 2023, Dr. Hanne Frøkiær will be elaborating on the topic of polyphenols and immunomodulation.You can learn more about the topics that will be discussed during the conference here.

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Polyphenols Applications 2023 Congress
September 27-29, 2023 - Malta
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