Spain Polyphenols Applications is postponed to 2021

Dear Colleagues,


In response to the critical situation and evolution of the COVID-19, the Organizing Committee of Polyphenols Applications 2020 decided to postpone the congress to next year.


The new date is September 23-24, 2021.
We will announce the details as soon as the planning of the 2021 meeting has been completed.


We will keep your registration, you don’t need to do anything.  In case of cancellation, the Organizing Committee will fully refund you.
Thank you for your understanding of this exceptional situation.


We will keep our optimism and wish rapidly to overcome these moments.


All our warm regards,


Prof. Dr. Andreas Schieber                      
President of Polyphenols Applications 2020
University of Bonn, Germany 


Molecular basis of the specificity and efficacy of resveratrol against cancer

wolfgang graier polyphenols 2017Professor Wolfgang F. Graier from the Institute of Molecular Biology and Biochemistry and Medical University of Graz, will give a talk at the 11th World congress on Polyphenols Applications about the molecular basis of the specificity and efficacy of resveratrol against cancer.

According to Prof. Graier, resveratrol and its derivate piceatannol are found to selectively cancer cell death.Professor Graier team work concentrated on the molecular mechanisms of this cancer selectivity. They observed that the functionally and/or physically tethering of the mitochondria to the endoplasmatic reticulum is greatly enhanced, thus, leading to an attenuated engagement of mitochondria to the cancer cells energy metabolism and ER ATP homeostasis.

The polyphenols take advantage of the enforced inter-organelle coupling and trigger apoptotic cancer cell death by their rather exclusive reduction of mitochondrial ATP content that affects ER Ca2+ handling yielding mitochondrial Ca2+ overload and subsequent cancer cell death.

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