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Latest Updates: Polyphenols Applications 2023

Please find below the latest updates about this year's World Congress on Polyphenols Applications:

Final Agenda & List of Posters

Updated Conference Agenda.

Presenters are asked to note down their presentation’s timing.

Posters’ List.

Poster presenters are asked to note down the number of their poster and day of their presentation. 

 Important Information for In-Person Participation

Venue Details: The conference will be held at Corinthia Palace Malta, De Paule Avenue, BZN 9023 San Anton, Malta. 

More venue details.

Badge Pick-up: You can start collecting your badges on September 28, starting 8:00 am.

 Important Information for Online Participation

Zoom Link: Online attendees will be provided with the conference zoom link 1-2 days prior to the conference.

Please dont hesitate to contact the organizing committe for more information.

Polyphenols Applications 2023 Congress
September 29-29, 2023 - Malta
Website | LinkedIn | Facebook

Polyphenols Applications 2023 Speakers' Dinner

Polyphenols Applications 2023 dinner will be organized on Thursday September 28 at Corinthia Palace Hotel Malta. 

You can join this dinner from 8:00 PM. It is a perfect opportunity to have an interactive discussion.

You can participate to the dinner by registering here.

Don't hesitate to contact the organizing committee if you have any questions.

Polyphenols Applications 2023 Congress
September 29-29, 2023 - Malta
Website | LinkedIn | Facebook

Polyphenols Applications 2023 Posters List

More than 120 communications will be presented next week in Malta during Polyphenols Applications 2023. Learn about the 70+ posters that will be presented in person/ online. Access full posters list.

Polyphenols Applications 2023 Congress
September 29-29, 2023 - Malta
Website | LinkedIn | Facebook

Polyphenols Innovation Network: Call for Projects

Please find here more information about the "Polyphenols Innovation Network" (PIN) & its projects.

Polyphenols Innovation Network

We are delighted to announce the launch of the Polyphenols Innovation Network (PIN), a pioneering initiative designed to accelerate progress in the field of polyphenols research by fostering a collaborative and innovative environment.

Aim of the Network

Under the banner of PIN, our mission is to assemble a diverse team of multidisciplinary experts, committed to advancing the frontiers of polyphenols research, applications, and innovation.

Projects of PIN

Three pioneering projects have been earmarked for initiation under the auspices of PIN:

Project 1: Artificial Intelligence and Polyphenols

This project will utilize AI's power to delve deeper into the understanding and utilization of polyphenols, aiming to develop predictive models for identifying novel therapeutic polyphenols and optimizing their formulations. 

Learn more.

Project 2: Longevity & Polyphenols

Our focus here is on exploring the role of polyphenols in promoting longevity and preventing age-related diseases. We aim to uncover the molecular mechanisms through which polyphenols exert their beneficial effects on lifespan and healthspan.

More details.

Project 3: Space Food & Polyphenols

This project centers on creating polyphenol-enriched space food to boost astronauts' nutrition and well-being during space missions.

Learn more.

Funding of Projects

The Polyphenols Innovation Network is dedicated to securing necessary resources from public and private institutions to support these groundbreaking efforts.

How to participate?

To contribute to one of these 3 pioneering projects, Polyphenols Applications requests interested researchers and teams to submit a proposal detailing the following aspects:

• Project Overview: Please provide a concise description of your current research or project. Include key goals, methodologies used, and any preliminary results or findings that could highlight the relevance and potential impact of your work.

• Alignment with PIN Goals: Articulate how your work contributes to the broader objectives of PIN. This could be in terms of techniques being developed, the specific aspects your project focuses on, or the potential applications of your research.

• Challenges and Solutions: Identify any potential hurdles or obstacles you anticipate in the course of your research. This could be technical issues, logistical constraints, or theoretical problems. Additionally, provide an outline of how you propose to tackle these challenges. This shows proactive problem-solving and can help us better understand the feasibility of your project.

• Team Profile: Furnish an overview of your team and its expertise. Highlight the skills, qualifications, and experiences of your team members that make them well-equipped to carry out the proposed project. Include any past achievements or relevant projects that demonstrate your team’s capacity to successfully execute the research.

We invite interested researchers and teams to join PIN by submitting their project proposals to projects(at)polyphenols-site.com by September 12.

Submissions should include a project overview, its alignment with PIN's goals, anticipated challenges and proposed solutions, and a team profile. Proposals will be evaluated by our Selection Committee, and successful applicants will be invited to participate in the next phase of our initiative.

Polyphenols Innovation Network
September 28-29, 2023 - Malta

Natural polyphenol supplements reduce dietary iron absorption in adults with iron-loading diseases

Prof. Michael Bruce Zimmermann, ETH Zurich, Switzerland, will join the Polyphenols Applications 2023 Congress and present his latest rearch about the "Natural polyphenol supplements reduce dietary iron absorption in adults with iron-loading diseases".

Dr. Zimmermann and his colleagues developed a new natural polyphenol supplement that strongly chelates iron in vitro and assessed its effect on non-heme iron absorption in patients with hereditary hemochromatosis (HH). The polyphenol supplement reduced iron absorption by ~ 40% from meals and test drinks.

Their results indicate that when taken with meals, this natural polyphenol supplement can decrease dietary iron absorption, and might thereby reduce toxicity of body iron accumulation in patients with HH.

Join us in Polyphenols Applications 2023 to learn more about Prof. Zimmermann's talk. 

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com

Polyphenol-Microbiome Interactions & Future of Nutrition

Dr. Tiffany Weir, Colorado State University USA, will join the Polyphenols Applications 2023 Congress and present her latest rearch about the interactions between polyphenols and the microbiome. 

Although consumption of dietary polyphenols is widely acknowledged as beneficial for human health, there is a high degree of variability in individual responses. Some of this variability may be due to differential processing of dietary polyphenols by the gut microbiome. Polyphenol metabolizing enzymes in the gut microbiota can influence the bioactivity and bioavailability of these compounds.

Dr. Weir and her colleagues are working to understand whether these polyphenol metabolizing enzymes are predictive of individual responses in vascular endothelial function to a dietary blueberry intervention in post-menopausal women. More broadly, understanding polyphenol metabolism in the gut will advance precision nutrition and potentially help identify complementary approaches to improve outcomes to nutrition interventions.

Dr. Weir will give a presentation titled: "Polyphenol-Microbiome Interactions & Future of Nutrition"

About Dr. Weir

Dr. Tiffany Weir is a professor of Food Science and Human Nutrition at Colorado State University. She leads an interdisciplinary translational research program focused on identifying the role of the gut microbiota in mediating diet-host interactions for improved cardiometabolic outcomes. Dr. Weir is the coordinator of the Microbiome Network, an interdisciplinary research and education consortium of microbiome scientists at Colorado State University. She also served as the Specialty Chief Editor for the Nutrition, Metabolism, and Microbiomes section of Frontiers in Microbiomes and is currently the Editor-in-Chief for npj Biofilms and Microbiomes.

Join us in Polyphenols Applications 2023 to learn more about Prof. Weir's talk. 

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com

Polyphenols & Immunomodulation: What do we know?

Prof. Hanne Frøkiær, University of Copenhagen, Denmark, will join the Polyphenols Applications 2023 Congress and present her latest rearch about the "Polyphenols & Immunomodulation: What do we know?".

Join us in Polyphenols Applications 2023 to learn more about Prof. Frøkiær's talk. 

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com

Role of Polyphenolic Caffeoylquinic Acids in the Neurological Effects of Centella asiatica

Dr. Amala Soumyanath, Oregon Health & Science University, USA, will join the Polyphenols Applications 2023 Congress and present his latest rearch about the "Role of Polyphenolic Caffeoylquinic Acids in the Neurological Effects of Centella asiatica".

The traditional herbal remedy, Centella asiatica, shows remarkable effects related to cognitive function and mood in preclinical models.  Its abundant triterpene constituents are usually reported as the active compounds.

However,  studies conducted by Dr. Soumyanath and her colleagues, show that polyphenolic caffeoylquinic acid isomers also play an important role in this herb’s neurotropic effects in vitro and in vivo.

Join us in Polyphenols Applications 2023 to learn more about this topic.

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com

Sustainable sources for Polyphenols Recovery and their Application in Healthy Food

Dr. Isabella D’Antuono from the Institute of Sciences of Food Production National Research Council (ISPA – CNR), Italy, will join the Polyphenols Applications 2023 Congress and present the talk entitled "Sustainable Sources for Polyphenols Recovery and their Application in Healthy Food".

Functional foods are an innovative response of food industries to consumer expectations. Their sector includes foods naturally rich in bioactive compounds or enriched in bio-ingredients stemming from unexploited sources, as a virtuous application of the circular economy concept.

Join us in Polyphenols Applications 2023 to learn more about Dr. D’Antuono's talk. 

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com

Deglycosylation of secondary plant metabolites by lactobacilli

Prof. Michael Gänzle, University of Alberta, Canada, will join the Polyphenols Applications 2023 Congress and present his latest rearch about the "Deglycosylation of secondary plant metabolites by lactobacilli".

Lactobacillaceae are among the major fermentation organisms in food fermentations but their metabolic pathways for conversion of (poly)-phenolic compounds have been elucidated only in the past two decades. The first step of conversion is the hydrolysis of esters or glycosides of phenolic compounds. This study aimed to evaluate the ability of Lactobacillus crispatus FUA3540, Companilactobacillus paralimentarius FUA3121, Lacticaseibacillus paracasei FUA3413, Lactiplantibacillus plantarum TMW1.460, Levilactobacillus hammesii LP38^T, Furfurilactobacillus rossiae FUA3124, and Ff. milii FUA3430^T and Fructilactobacillus sanfranciscensis DSM20451^T to hydrolyse glycosides of secondary plant metabolites.

The genomes of these strains encoded for 5, 20, 8, 10, 2, 1, 2 and 0 β-glucosidases or phospho‑β‑glucosidases, respectively. L. crispatus, Cp. paralimentarius, Lc. paracasei and Lp. plantarum but not Lv. hammesii, Ff. rossiae or Ff. milii hydrolysed cellobiose. The hydrolysis of amygladin, esculin, and salicin matched the hydrolysis of cellobiose. With exception of Fl. sanfranciscensis, all strains hydrolysed spiraeoside and genistin. Lp. plantarum and Cp. paralimentarius additionally hydrolysed isoquercetin.

Prof. Gänzle's data support the previous observation that many of the glycosyl hydrolases in lactobacilli are specific for glycosylated secondary plant metabolites rather than di- and oligosaccharides. Increased knowledge on their substrate specificity will facilitate the selection of fermentation organisms to secondary plant metabolites with desirable or undesirable biological activities in food fermentations.

Join us in Polyphenols Applications 2023 to learn more about Prof. Gänzle's talk. 

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com

Polyphenols in Depression & Neurodegenerative Diseases

Prof. Giulio Maria Pasinetti from Icahn School of Medicine at Mount Sinai, USA, will join the Polyphenols Applications 2023 congress and will present a talk entitled "Polyphenols in Depression & Neurodegenerative Diseases".

Join us in Polyphenols Applications 2023 to learn more about Dr. Pasinetti's talk. 

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com

Book your hotel and benefit from the best rate

Corinthia Palace Malta will be the conference hotel of Polyphenols Applications 2023 on September 28-29.

Hotel Booking for Attendees: Special Rate

This year's attendees will be able to benefit from a discount on their booking at the conference hotel.

Available rooms include: Deluxe double, executive double, and executive suites for sole use.

The room rate includes full breakfast and VAT. Please note that the offer is valid until July 31, with a limited number of rooms.

Book you room with a preferential rate now.

If you need more than 2 rooms, please contact the hotel directly via email, mentioning that you will attend Polyphenols Applications 2023.

More about the hotel and activities in Malta.

Registration Details

Register early and book your spot to to learn about this year's new scientific outlook on Polyphenols Applications in lovely Malta.

Polyphenols Applications Congress
September 28-29, 2023 - Malta

Plant-Derived Polyphenols as Senolytic Agents

Cellular senescence is a basic aging process that drives several age-related degenerative conditions.  Compounds that selectively eliminate senescent cells, commonly called “senolytics”, have the potential to improve multiple degenerative conditions by targeting this key age-promoting process. 

Several polyphenols have been shown to have senolytic activity, including the hops-derived chalconoid xanthohumol, presenting a new pathway by which these molecules might improve degenerative disease.  

Dr. Christopher Wiley from Tufts University, USA, will join the Polyphenols Applications 2023 congress and will present a talk entitled "Plant-Derived Polyphenols as Senolytic Agents".

 About Dr. Wiley

Dr. Wiley is a Scientist II at the Jean Mayer USDA Human Nutrition Research Center on Aging and an Assistant Professor in the School of Medicine at Tufts University.  His laboratory studies the interactions between metabolism and cell fate decisions such as cellular senescence and cell death, primarily in the context of aging and degenerative disease.  

Join us in Polyphenols Applications 2023 to learn more about Dr. Wiley's talk. 

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com

Cranberry Polyphenols Inhibit Esophageal Cancer Through Reshapeing the Microbiome-Metabolome Axis

Dr. Laura Kresty from the University of Michigan, USA, will join the Polyphenols Applications 2023 congress and will present a talk entitled "Cranberry Polyphenols Inhibit Esophageal Cancer Through Reshapeing the Microbiome-Metabolome Axis".

Join us in Polyphenols Applications 2023 to learn more about Dr. Kresty's talk. 

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com

Catechol-based Nanostructures in Medicine

Prof. Daniel Ruiz Molina from Universitat Autònoma de Barcelona, Spain, will join the Polyphenols Applications 2023 congress and will present a talk entitled "Catechol-based Nanostructures in Medicine".

The experience and background of the team brings an important asset in the synthesis of “sticky” catechol based coatings and nanoparticles with bioadhesion properties in humid conditions. This involves: I)  Synthesis of nanoparticles/nanocapsules intended for chemo-/phototherapy with encapsulated drugs and study of the controlled release, II) novel coating for biofunctionalization, colloidal stabilization in physiological media experimental conditions and III) a patch to damaged tissue that allow for the growth of healthy cells in a very effective way that will naturally induce a faster regeneration of the tissue.

Join us in Polyphenols Applications 2023 to learn more about Prof. Ruiz's talk. 

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com

Multi-omics Approach Reveal Biomarkers of Metabolic Resilience in Healthy Participants Supplemented With Grape Polyphenols

Dr. Diana Roopchand from Rutgers University, USA, will join the Polyphenols Applications 2023 congress and will present a talk entitled "Multi-omics Approach Reveal Biomarkers of Metabolic Resilience in Healthy Participants Supplemented With Grape Polyphenols".

Grape polyphenols (GPs) extracted from grape pomace are rich in proanthocyanidins (PACs) compounds which are not bioavailable; however, evidence suggests their health benefits are likely mediated via the gut microbiota and/or bacterial metabolites.

Serum, fecal, and/or urine samples were collected before and after 2, 4, and 10 days of GP supplementation followed by shotgun metagenomic sequencing, mass spectrometry-based metaproteomics, and/or targeted metabolomics. Notable GP-induced bile acid changes appeared to be gender-specific and correlational analyses uncovered novel associations between gut microbes and metabolites associated with metabolic resilience.

Join us in Polyphenols Applications 2023 to learn more about Prof. Roopchand's talk. 

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com

Phenolic Compounds, Bioaccessibility and Characterization in Foods

Prof. Trust Beta from the University of Manitoba, Canada, will join the Polyphenols Applications 2023 congress and will present a talk entitled "Phenolic Compounds: Their Characterization and Bioaccessibility in Cereal Foods".

Globally, cereal grains serve as a source of affordable, staple foods. They comprise minor phytochemicals which may function to reduce oxidative stress. Grain phenolics are among compounds of interest as they have been shown to exhibit antioxidant and anti-inflammatory functions. Their characterization and bioaccessibility in cereal grains will be discussed during this presentation.

Join us in Polyphenols Applications 2023 to learn more about Prof. Beta's talk. 

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com

Biological Activities of Phenol-Amino Acid Adducts: Towards enhancing Food Quality

Dr. Marianne Nissen Lund from the University of Copenhagen, Denmark will join the Polyphenols Applications 2023 congress and give a major presentation entitled "Biological Activities of Phenol-Amino Acid Adducts: Towards Enhancing Food Quality".

When polyphenols are oxidized to quinones they react with proteins in foods, with cysteine residues on proteins being kinetically preferred targets. Caffeic acid-cysteine and chlorogenic acid-cysteine adducts have been detected in commercial coffee-milk drinks. Thus, these adducts were synthesized and their anti-inflammatory activity was tested in lipopolysaccharide-treated RAW 264.7 cells in comparison to their parent phenolic acids.

Dr. Lund's results demonstrate that the addition of a cysteine moiety to phenolic acids enhances their anti-inflammatory responses in macrophages.

Join us in Polyphenols Applications 2023 to learn more about Dr. Lund's talk. 

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com

The Latest Advances in the Biotechnological Production of Phenolic Compounds

Dr. Matheos Koffas from the Rensselaer Polytechnic Institute, School of Engineering, USA will join the Polyphenols Applications 2023 congress and will give a major presentation entitled "The Latest Advances in the Biotechnological Production of Phenolic Compounds".

Join us in Polyphenols Applications 2023 to learn more about Dr. Koffas's talk during the session "Polyphenols & Food Research: The Most Recent Developments". 

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com

Dietary Polyphenols Inhibit Production of Trimethylamine, a Gut Microbial Metabolite Associated With Aging and Atherosclerosis

Prof. Andrew P. Neilson, North Carolina State University, USA, will join the Polyphenols Applications 2023 congress and will present a talk entitled "Dietary Polyphenols Inhibit Production of Trimethylamine, a Gut Microbial Metabolite Associated With Aging and Atherosclerosis".

Cardiovascular disease causes ~32% of deaths worldwide. Elevated blood trimethylamine N-oxide (TMAO) levels were identified in 2011 as a risk factor for atherosclerosis development. TMAO is formed through a microbial-host axis involving oxidation of dietary choline to trimethylamine (TMA) by gut bacteria containing the cutC/D gene cluster. TMA is absorbed into circulation and oxidized to TMAO by hepatic flavin-containing monooxygenase 3. TMAO promotes cardiovascular disease through multiple mechanisms.

There is no FDA-approved drug to control TMAO levels, underscoring the need for complementary strategies to manage TMAO production. Dietary phytochemicals such as phenolics represent one potential solution. Phenolics have shown promise for altering the structure and function of the gut microbiome and providing cardioprotective benefits. Interest is emerging in TMAO-lowering activities of phenolics. There is a need to rapidly screen large numbers of phenolics and other dietary bioactives (compounds foods, extracts, etc.) to identify potential lead compounds for subsequent preclinical animal studies.

Prof. Neilson and his team developed and validated a high-throughput, low-volume 96-well ex vivo-in vitro anaerobic fecal fermentation method using human fecal samples and choline-d₉ substrate and measuring the resultant TMA-d₉. They paired this with a rapid, high-throughput analytical platform by employing an automated liquid handling robot for sample prep and a fast, sensitive 96-well LC-MS/MS method. Model validation experiments confirmed that choline-d₉ utilization and TMA-d₉ production occur with ~1:1 stoichiometry, with no background interference, and are dependent upon the presence of gut bacteria. Using this model, they identified chlorogenic acid, epicatechin and foods rich in these phenolics (coffee, cocoa and artichoke) as potent TMA production inhibitors.

In vitro and animal studies will elucidate the mechanisms of inhibition and demonstrate efficacy in vivo. TMA/TMAO-lowering activities may be a previously unknown mechanism by which dietary phenolics exert their cardioprotective effects.

Join us in Polyphenols Applications 2023 to learn more about Prof. Neilson's talk. 

Polyphenols Applications 2023 Congress
September 28-29, 2023 - Malta
www.polyphenols-site.com