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Polyphenols Applications 2021 World Congress

 

On behalf of the Scientific Committee of the International Society of Antioxidants (ISANH), we are excited to announce the organization of the 14th World Congress on Polyphenols Applications which will be organized on September 23-24, 2021 as 100% Digital Congress.

Dietary flavonols and risk of Alzheimer dementia

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Objective To determine whether dietary intake of flavonols is associated with Alzheimer dementia.

Methods The study was conducted among 921 participants of the Rush Memory and Aging Project (MAP), an ongoing community-based, prospective cohort. Participants completed annual neurologic evaluations and dietary assessments using a validated food frequency questionnaire.

Results Among 921 MAP participants who initially had no dementia in the analyzed sample, 220 developed Alzheimer dementia. The mean age of the sample was 81.2 years (SD 7.2), with the majority (n = 691, 75%) being female. Participants with the highest intake of total flavonols had higher levels of education and more participation in physical and cognitive activities. In Cox proportional hazards models, dietary intakes of flavonols were inversely associated with incident Alzheimer dementia in models adjusted for age, sex, education, APOE ɛ4, and participation in cognitive and physical activities. Hazard ratios (HRs) for the fifth vs first quintiles of intake were as follows: for total flavonol, 0.52 (95% confidence interval [CI], 0.33–0.84); for kaempferol, 0.49 (95% CI, 0.31–0.77); for myricetin, 0.62 (95% CI, 0.4–0.97); and for isorhamnetin, 0.62 (95% CI, 0.39–0.98). Quercetin was not associated with Alzheimer dementia (HR, 0.69; 95% CI, 0.43–1.09).

Conclusion Higher dietary intakes of flavonols may be associated with reduced risk of developing Alzheimer dementia.


Authors: Thomas M. Holland, MD, Puja Agarwal, PhD, Yamin Wang, PhD, Sue E. Leurgans, PhD, David A. Bennett, MD, Sarah L. Booth, PhD, and Martha Clare Morris, ScD
Journal: Neurology® 2020;94:1-8. doi:10.1212/WNL.0000000000008981