Rethinking Polyphenols and Their Metabolites: Is Mitochondrial Competence the Missing Link?
Why can the same polyphenol produce different effects in different people, tissues or metabolic conditions? Marvin Edeas of Université Paris Cité, France, will explore how the answer may lie in the mitochondria.
Polyphenols are transformed by gut microbes and the body into metabolites that circulate and interact with our cells. Their effects may depend on mitochondrial competence: the ability of mitochondria to sense and respond to metabolic and environmental signals. Ageing, chronic inflammation and metabolic disease may alter this ability—and, in turn, how cells respond to polyphenol-derived signals.
In his lecture, Prof. Edeas will discuss the interplay between polyphenols, microbial metabolites and mitochondria, and consider how mitochondrial competence could help explain differences in response to nutrition interventions. The concept may also offer new perspectives on precision nutrition, healthy ageing and disease prevention.
