Effects of Cocoa Extract and a Multivitamin on Cognitive Function


News release, Polyphenols Applications - 15 September 2022, Valencia - Spain

Dietary supplements are touted for cognitive protection, but supporting evidence is mixed. COSMOS-Mind tested whether daily administration of cocoa extract (containing 500 mg/day flavanols) versus placebo and a commercial multivitamin-mineral (MVM) versus placebo improved cognition in older women and men. This large randomized two-by-two factorial 3-year trial, assessed cognition by telephone at baseline and annually.

The primary outcome was a global cognition composite formed from mean standardized (z) scores (relative to baseline) from individual tests, including the Telephone Interview of Cognitive Status, Word List and Story Recall, Oral Trail-Making, Verbal Fluency, Number Span, and Digit Ordering. Using intention-to-treat, the primary endpoint was change in this composite with 3 years of cocoa extract use. The pre-specified secondary endpoint was change in the composite with 3 years of MVM supplementation. Treatment effects were also examined for executive function and memory composite scores, and in pre-specified subgroups at higher risk for cognitive decline.

Cocoa extract did not benefit cognition, but  MVM showed potential efficacy to improve cognition in older adults. Additional work is needed to confirm these findings in a more diverse cohort and to identify mechanisms to account for MVM effects.

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Polyphenols Applications 2022 Congress
September 28-30, 2022 - Valencia, Spain