Bioactivity, bioavailability, and gut microbiota transformations of dietary phenolic compounds: implications for COVID-19

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The fate of dietary PC during human digestion

This excellent review by  Augusti PR et al. explained the implications of dietary phenolic compounds consumption on COVID 19.

The coronavirus disease-19 (COVID-19) is known to target multiple organs through inflammatory, immune, and redox mechanisms, yet no effective drug has been identified for its prophylaxis or treatment. The use of dietary bioactive compounds, such as phenolic compounds (PC), has emerged as a putative nutritional or therapeutic adjunct approach for COVID-19.

The following paper reviews the mechanisms underlying the bioactivity of PC and their usefulness in COVID-19 mitigation. Antioxidant, antiviral, anti-inflammatory, and immunomodulatory effects of dietary PC are studied. Also, the implications of digestion on the putative benefits of dietary PC against COVID-19 are presented by addressing the bioavailability and biotransformation of PC by the gut microbiota. Last but not least, safety issues and possible drug interactions of PC and their implications in COVID-19 therapeutics are discussed.

A specific sessions will be dedicated to polyphenols and infection in our 15th world congress, to be held in Spain next year.

Authors: Augusti PR, Conterato GMM, Denardin CC, et al. 


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