From Polyphenol Metabolism to Precision Nutrition: Advancing Translation to Human Health

Prof. Pedro Mena will present on the strategic topic: "From Polyphenol Metabolism to Precision Nutrition: Advancing Translation to Human Health" at Polyphenols Applications 2026 which will be held in Malaga, Spain on October 8-9.

Why do some individuals benefit more than others from dietary polyphenols? Growing evidence shows that inter-individual variability in the metabolism and biological response to these compounds is a key factor shaping their effects on obesity and cardiometabolic health. Rather than being a limitation, this variability offers a powerful opportunity to develop precision nutrition strategies based on phenolic metabotypes. In this lecture, we will present findings from the Oral Polyphenol Challenge Test, a large acute intervention study in 300 subjects, which enabled the identification of distinct metabotypes associated with differences in dietary habits, microbial composition, genetic background, and cardiometabolic traits. We will also discuss how integrated multi-omics approaches, combined with advanced analytical platforms, are helping to uncover the main determinants of (poly)phenol metabolism. Finally, preliminary results from the PRE-CARE-DIET randomized controlled trial will illustrate how personalized, sustainable, (poly)phenol-rich diets may improve cardiometabolic health and support the translation of polyphenol science into clinically relevant nutrition.

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